Redox mechanisms in hepatic chronic wound healing and fibrogenesis
نویسندگان
چکیده
منابع مشابه
The role of redox mechanisms in hepatic chronic wound healing and fibrogenesis
Under physiological conditions, intracellular and tissue levels of reactive oxygen species (ROS) are carefully controlled and employed as fine modulators of signal transduction, gene expression and cell functional responses (redox signaling). A significant derangement in redox homeostasis, resulting in sustained levels of oxidative stress and related mediators, plays a role in the pathogenesis ...
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976 Wound healing disorders represent an important medical problem. This is particularly relevant for the elderly, who frequently suffer from complex disease states such as diabetes, venous stasis, or physical immobility, contributing to the development of chronic ulcers. In 1996, 6.5 million people in the U.S. suffered from skin ulcers, with the annual costs for diabetic ulcer treatment alone ...
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Oxygen is a prerequisite for successful wound healing due to the increased demand for reparative processes such as cell proliferation, bacterial defence, angiogenesis and collagen synthesis. Even though the role of oxygen in wound healing is not yet completely understood, many experimental and clinical observations have shown wound healing to be impaired under hypoxia. This article provides an ...
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ژورنال
عنوان ژورنال: Fibrogenesis & Tissue Repair
سال: 2008
ISSN: 1755-1536
DOI: 10.1186/1755-1536-1-5